Botox generally takes effect within 5-7 days. Rarely, the effects can take 10 days to settle into the face. You will notice that the muscle action causing brow furrowing, crow's feet and horizontal forehead lines lessen as Botox takes effect. Subsequently, the resting lines associated with these movements fade away! The result is lifted brow position, a smooth forehead, no more 11 lines between the brows and softened crow's feet around the eyes!