Hello and thank you for your question. Although Kybella has been FDA approved, the area it is approved for is the submental fat area. However, there are entire courses devoted to Mesotherapy (Google defines Mesotherapy as-(in cosmetic surgery) a procedure in which multiple tiny injections of pharmaceuticals, vitamins, etc. are delivered into the mesodermal layer of tissue under the skin, to promote the loss of fat or cellulite) in which jowl reduction is an option. Whatever you decide to use, just make sure you know and trust the provider. You are correct in having concerns of loose skin after you dissolve the fat and that is definitely a possibility. A great option to consider to help with this is the use of PDO Threads. You can do an amazing things with PDO Threads and lift the jowl area with minimal bruising or downtime. Hope this answer helps and best of luck from the Art of Ageless Aesthetics.