Hello!
You will continue to experience dry skin and lips throughout the course of isotretinoin (Accutane). For most patients, the course of treatment is about 6 months; however, every patient is different, so ask your dermatologist about specific expectations for you.
Some patients notice a slight improvement in dryness over the course of treatment, but this is likely related to consistent use of moisturizers and lip treatment. I like Cerave and Cetaphil creams, and aquaphor lip therapy or Dr. Dans Cortibalm for my patients. Always use gentle cleansers to limit extra irritation, as well.
The good news is that the dryness goes away within a month of stopping isotretinoin, and you will emerge with clear, acne-free skin!
Best of luck!