Without performing a thorough clinical and radiographic examination it is impossible to address your specific question. The asymmetry can be dental or skeletal (This cannot be answered through one frontal smiling photo). This means the problem may lie within the positions of the jaws or the positions of the teeth. A thorough examination can indicate whether the underlying problem is dental or skeletal. If the problem is dental, Invisalign can absolutely address this problem. If the problem is skeletal then orthognathic surgery is needed to correct the problem. I hope this addresses your concerns.