Both SculpSure and CoolSculpting destroy about the same amount of fat with each treatment. However, SculpSure has a few advantages. First, the treatment time is 25 minutes per area compared to about 1 hour with CoolSculpting. SculpSure also has some heat spread just outside of the treatment area which gives a smoother transition from treated to untreated area. There is zero downtime with SculpSure and most people have no discomfort after the treatment where some people have lingering discomfort and/or numbness for a few weeks after CoolSculpting. Whichever method you choose, keep in mind that you will likely need 2-3 treatments per area to get the desired results.
For loose skin, some have noticed that SculpSure may give a slight tightening but this is not a claim from SculpSure itself. There are radiofrequency devices that can help such as Exilis Ultra. Tightening results are subtle and take time with multiple treatments.