Liquid Silicone Injections: XXI Century Epidemia.


In 1898 Robert Gersuny, Austrian surgeon, developed a metod to injected paraffin into the patient’s scrotum who was orquiectomized (testicles removed) because suffer testicular tuberculosis.
Here started the beginning of the history of the injection of substances to give facial and body volumen augmentation.
This practice became very popular and spreaded over europe. 12 years later there were whole chapters in plastic surgery text books which explained how to try to correct and rebuild the serious sequelae secondary to the application of paraffin. In 1947 during the Vietnam War, the use of liquid silicone that was used to waterproof the decks of aircraft carriers and tanks, breast enhancement of oriental women who by their genetic lack of volume in these countries became popular.
Parallel to the war there was another disaster with hundreds of thousands of women who were injected with liquid silicone.
After the war the problem moved to the United States, and public health problem was so big that in the state of Nevada was considered a federal crime to cross state lines with liquid silicone. Liquid silicone is currently marketed under different names:

• Silikon 1000 (Alcon Laboratories, Fort Worth, Texas) has been U.S. Food and Drug Admin- istration approved for retinal reattachment since 1998.
• SilSkin, 1000 cS (Richard-James Development Corp., Peabody, Mass.) is in clinical trials

Later, appeared substances like hydrogel poly acrylamyda PAG (1988 - 2009) that started in Ukraine and spread throughout Europe and Asia, receiving licenses that were subsequently canceled by the large number of patients with complications, some countries still freely allow their application .:

• Aquamid (Ferrosan AS, Copenhagen, Denmark) polyacrylamide gel 2.5% in water.
• Interfall (Interfall Ltd., Kiev, Ukraine).
• Bio-Alcamid (Polymekon, Milan, Italy); 4% polyacrylamide cross-linked with polyalkylimide.
• Outline (ProCytech, Bordeaux, France) is tem- porary and absorbed within 1 to 2 years
• Amazing Gel (FuHua Ltd., ShenZhen, China).
• Formacryl (Bioform, Moscow, Russia)
• Argiform (Bioform) with silver ions as an anti- biotic.,

In 1991 poly methyl methacrylate PMMA treatment became licenced to treat HIV patients but not to use it on patients without HIV and its application in face, breasts, buttocks, calves, etc. Spread broadly. Currently it is a crime in some countries to apply this product and it must be payed with jail. This product also has been reported with a large number of patients with complications and sequelaes in various countries:

• Artecoll (Rofil Medical International, Denmark) consists of microspheres 30 to 42 M in diameter, sus- pended in bovine collagen.
• ArteFill (Artes Medical, San Diego, Calif.) con- sists of microspheres 30 to 50 M in diameter but more highly purified than those in Arte- coll; the microspheres are suspended in bovine collagen manufactured in the United States.
• Aphrodite Gold (European Medical Contract Manufacturer, Nijmegen, The Netherlands) is the former Artecoll in a new package, distributed outside Europe and the United States.
• Metacrill (Nutricel Laboratorios, Rio de Janeiro, Brazil); polymethylmethacrylate microspheres 1 to 80 m in diameter, with impuri- ties similar to those of the former Arteplast, suspended in carboxygluconate gel.
• Bioplasty (Dr. Almir Nacul, Porto Alegre, Brazil) is similar to Metacrill.
• Precise (Clinica Estetica, Tijuana, Mexico) is similar to Metacrill.

In 2007 appeared the Macrolane:

• Macrolane
(Q-Med, Uppsala, Sweden; and Medicis Aesthetics, Scottsdale, Arizona, USA.)

Which found numerous medical articles which demonstrated the use and risk of catastrophic complications have arisen.

Patients developes allogenosis Iatrogenic (allogenic: strange substance, Iatrogenic: corporal lesion caused by another person) minds degeneration of tissues secondary to inyected product and an autoimmune syndrome known as A.S.I.A. (Autoimmune inflamatory Syndrome Induced by Adjuvants), a set of symptoms similar to autoimmune disease which worsens the patients prognosis.

There is no safe permanent fillers to be applied on the face or body, as written above, including those approved by the health authorities of different countries in Europe, Asia or Latin America.

So far the industrialized product with the lowest number of complications is hyaluronic acid (Juvederm, Allergan), to be applied to the face in small quantities by area. Reabsorbed 1 to 2 years after application.

Be aware, do not let any permanenr filler to be injected into your face, breast, buttocks, calfs, genitalia, etc. The safest way to increase buttocks is through your own fat injections or through buttock silicone implants.

Hope I was helpful.
Article by
Colombia Plastic Surgeon