I had Botox in the year 2000. It worked GREAT and lasted 4 months. Then the second time it only lasted 6 WEEKS, the third time ..only 2-3 weeks. Very reputable doctor ( plastic surgeon)Soooo.... I gave up. Then I decided to try AGAIN in 2004. This time I had 33 Units which I was told was ALOT. Wellll...same thing happened. It lasted maybe 3 weeks at most. I was told there is approx. 1% of people who's body absorbs it quickly and it is therefor not effective. BUT why did it work the first time? So then in 2008 I gave it yet a 3rd try because I just cannot stand the frown lines..makes you look kinda angry. It was the same experience as before...only lasting 3-4 weeeks. He added MORE at the 3-4 week period and STILL,it lasted a very brief time. I was excited when Dysport came out ---thinking well maybe this will be the solution. Basicly they are the same except for the 'other ingredients' used.I went in after a week and he injected me again...adding to the first round. It has KINDA worked...BUT after 3 wks there is still movement and I am seeing as the days go by...even more movement. SO??? I am very frustrated to have spent sooo much money for basicly nothing...to simply be told I am in the 1% that these just do not work for. And I am just not a candidate for Botox and Dysport. I thought well maybe if I 'fix' the lines from my nose to my mouth I will feel better. I am sooo CONFUSED on WHICH to try though. The plastic surgeons nurse talked to me and was all in favor of Evolence.... I just don't know.Evolence or Artifil or Prevelle???Oh, and in 2008, I also tried Restylane and Radiesse for the lines from the nose to the mouth and around the mouth... and neither were long lasting.Then I tried Juvederm Ultra Plus and it seemed to work a bit better on the lines around it did not last very long...maybe 3-4 months, I think.I am wondering if evolence is the way to go since it is not HA based but collagen. As for the 'frown' lines...I am at a loss there also. Any suggestions? Anyone else had the same experience...where the botox, dysport, radiesse and restylane didn't work? and if it did ,did it only last a very short time? ( I did go to 3 different doctors as I was wondering if possibly it was being diluted or if it was something he was or was not doing right. But all 3 are known to have very good reputations. I would love to hear from anyone that has had the same experience. Thanks very much!