Yes, it's possible to get some growth from the creams. But, estrogen cream is lower in estrogen than pills or injections. I was on pills and then injections for 12 years, then had to stop all hormones for two years, after which I started using the creams on my breasts, which were already as big as they were going to get. After about a month I was surprised by the amount of nipple and areola growth I experienced. My nipples have always been larger than normal, but after using the creams for a month, they almost doubled in size. When erect they measure right at one inch long and just under a half inch across. But to see appreciable breast growth, you really need more estrogen than the cream will supply.