I’ve had both Radiesse and Restylane in my tear troughs and nasiolabial folds, all at different visits. I can definitely tell you which one I liked better!
I found Radiesse to be far superior. First off, both times with Radiesse in the same areas as I’d had Restylane and with the same RN, the pain, bruising and swelling was less. Recovery time is really important to me and everyone is different but my experience says Radiesse all the way!
I also thought the results with Radiesse in my tear troughs and NL folds were better. I had some tiny, pin-sized lumps with Restylane whereas Radiesse was exceptionally smooth. I loved rubbing my cheeks and feeling the difference, nevermind the difference in the mirror (that was also great). I definitely had a more powerful result with Radiesse that gave me the look I wanted to achieve.
The third factor: longevity. Radiesse was a clear winner here too. Restylane is notorious for lasting maybe three months. I had some results until the third month but two was the real result. It really tapered off after that. Radiesse lasted six - yes SIX! – months in my tear troughs and about four in my NL folds. For the price I thought this was superb!
Hands down, in my experience Radiesse is the better dermal filler. I won’t be trying Restylane anywhere else and I doubt I’ll even try newer products like Juvederm. Radiesse has far exceeded my expectations. I don’t need to look elsewhere. I love it!

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