I tried OTC treatments, topical antibiotics, oral antibiotics, and topical retinoids. Isotretinoin is the only medication i found to be effective for my severe acne. I did not experience depression while on the tane, but I can see how the drug can exacerbate existing psychological issues. The drug kind turned me into a zombie for the duration of the treatment. I took about a 7g-10g cumulative dosage. I had to stop because of headaches/i need mental ability for my job. 90% skin improvement. If you have severe acne and can handle the side effects, highly recommended. Buy aquaphor(no vaseline) and cetaphil(or equivalent) to prevent lip chapping and skin dryness.