I am part of a trial here in WA. state through my doctor's office - so was injected with Juvaderm in November. The naso-labial folds was the test site - and overall I'm elated with the results. I did bruise a bit more with these than injections from Restylane in the same site, where I hardly bruised. There was a topical applied, but unlike Restylane which can burn somewhat - I didn't feel any sensation at all with the Juvaderm. I'm going to have it injected into my lips next month.