I jumped on the injectable bandwagon at the age of 47 and I am now 50. I usually do the peremiter of the lips, upper as well as the corners to turn my mouth up. Also on my slight nasolabial folds and marionette lines. I have never had any problems. When I went for my twice yearly juvederm treatment the injector advised me to do the full syringe on my left side as my face was starting to lose its symmetry. I had never even thought of this and no one had mentioned it to me in previous injecting sessions. After a few days when the swelling went down I asked my family if both sides looked the same and they said yes. I wanted to make sure that the size that received the juverderm did not look off kilter. The side where I needed the filler is the side I sleep on. Obviously the injector was right about my face needing volume on one side.