I was a test patient for Radiesse. My doctor decided to consider using it as a filler and needed test patients, so I was blessed enough to get in on the action.
I am 33 and have fairly deep Nasolabial folds. The drug did not completely erase the lines, nor did I want them to. It did, however, soften them and make my face look a little fuller like it did in my early and mid twenties.
I highly recommend Radiesse!
I think the most important part of the treatment is finding the best surgeon / dermatologist in your area. I went to a plastic surgeon for my procedure.