My lashes just about disappeared as I began menopause. I always looked tired unless I used eyeliner combined with "tube mascara".
I began applying Latisse June 6th '09. It's been just about 3 months and what an incredible difference! I have NO reason to wear either liner or mascara! My lashes are thick, dark, and long. At first they were growing at all angles but as time progressed they were straight again.
I do not use the applicators included but rather a thin eyeliner brush. I also find that using 1 drop (placed in the bottle cap) is enough to do both the upper and yes lower lashes. The skin darkness is minimal if you are careful applying the product. I've hazel eyes that are still hazel. I purchased Lumigan for the 2nd bottle (cheaper and I didn't need those nasty applicators).
Yes there are days my eyes are a bit itchy but I've found if I apply the stuff around 7pm I don't experience that anymore. I also did not experience the lashes falling out as yet. I do use an eyelash curler and haven't had "any" loss.