Xeomin vs. Botox - Which is Better?
- Asked 4 years ago
Xeomin is an FDA-approved alternative to Botox for glabellar wrinkles
Xeomin and Botox work the same way to paralyze muscles and smooth wrinkles. They share the identical active ingredient - botulinum toxin A. The difference is that Botox has an accompanying protein, but xeomin is naked. In the skin, all of the protein detaches from Botox within 1 minute of injection so there is no reason why the effect of xeomin should differ from Botox. Xeomin has proven effective in clinical trials. It is approved in Europe and the US to diminish glabellar (between the eyebrow) wrinkles. I have had good results with it.
Time will tell
I've asked myself the same question. I am still not ready to recommend Xeomin use to my patients for a few reasons. I should also point out that I am in the process of completing a very large study comparing Botox, Dysport and Xeomin using only the highest quality research (a meta-analysis). Here is a link to the study I am doing. You can search online for A comparative assessment of three formulations of botulinum toxin A for facial rhytides: a systematic review and meta-analyses to read the project we are working on.
Like all businesses, there is a lot of marketing. Xeomin's claims to fame are #1 you dont need to refrigerate it and #2 there is less risk of allergies. After reviewing over 20,000 patients in a number of randomized studies, there are no reports of allergies with botox. Yes, there are reports of this happening in other series but it is extremely rare thus I dont believe that Xeomin offers any advantage in this regard. At this point, there is absolutely no evidence one is better than the other. Its just marketing based on "theory."
Also, Botox is such a popular brand now, people ask for it by name. I think many people are nervous about trying a product that has been on the market for a few years versus one that has been around over 15 years. I tend to use Botox cause I know it works, its safe and people are happy with the results.
Also, there is evidence that Xeomin may not last as long as Botox. Now, this is controversial but hopefully the study I am doing will answer this question. At this time, there is no reason to believe one lasts longer than the other, however....time will tell.
Finally, one of the "benefits" of Xeomin is that it is considered a more purified version of the active component of the toxin. Basically, botulinum toxin contains an active component (the part that results in the key effect) and some other proteins. Xeomin removed these proteins and thus the notion that there is less of a risk of allergy as some believe the allergy risk is associated with these proteins. However, there is another side to the story. Some people suggest that these proteins are important for making the medication work better, thus some believe this is the reason why Botox may last longer, it keeps some of these "extra" proteins that may have a role in improving its effect.
Wheww...Long winded I know, but its a complicated topic and one I find interesting.
I think I'll end by saying, I dont know what the right answer is, it may turn out there is no difference between products. But as a physician, my goal is to treat people with a medication that I believe is the safest and most effective available. At this point, Botox is that product. Perhaps my opinion will change once more evidence is out there, but for now, I continue to recommend Botox.
Xeomin is similar to Botox and possibly cheaper to the patient.
Xeomin is another Botulinum toxin A like Botox and Dysport with a very similar safety profile and effectiveness. I have used all three and find that each works very effectively when used to reduce wrinkles and shape your brow position. Hope this helps..Laurie A. Casas,MD
Web reference: http://www.casas.md/botox/
Recent Xeomin Reviews
Xeomin Vs. Botox
Xeomin is another neurotoxin - it is in the same category as Botox and Dysport. It has been used in Europe for many years. It has less proteins then Botox, possibly making it less stable and possibly reducing the chance of resistance. We have been using it in our office for a while and have had results consistant of Botox so far - however the cost to the consumer is cheaper with Xeomin as it stands now.
Dr. Grant Stevens
Xeomin - Great For Patients
Xeomin is finally approved here in the United States and offers several major advantages.
- Xeomin does not have any additives, i.e. is a naked botulinium toxin, it has less risk of antibody formation. This has the theoretic advantage of patients less likely to develop resistance to Xeomin.
- Xeomin does not have to be refrigerated
- Xeomin works essentially the same as Botox. Same duration, amount of time, dosing, etc. This familiarity makes it a much easier product for physicians and patients to adopt to.
- Xeomin will drive the overall price of botox down.
- Has been used in Germany for more than 3 years but product is very similar to Botox.
Web reference: http://www.shahfacialplastics.com/botox-injection.html
Xeomin is similar to Botox, but not the same
Xeomin VS Botox VS Dysport
Xeomin, produced by Merz Pharma, has been used in Europe since 2008 AND has become available in the US in Nov 2011. It IS being used in Austria, Canada, Germany, Denmark, Finland, France, Italy, UK, Luxembourg, Norway, Poland, Portugal, Spain, Sweden, Argentina and Mexico.
The company claims that 1 unit of Xeomin is equivalent to 1 unit of Botox. The SUPPOSED advantage, yet to be proven of Xeomin over Botox is that by removing complexing proteins higher doses, as are needed in spastic disorders care, can be given without resulting in antibody formation. With the doses used for facial cosmesis this is not a major concern in my opinion.
I have used ALL these toxins and so far the Xeomin proved equal to Botox at a cheaper price.
Dr. P Aldea
I have many patients that have tried both since both of them work the same. Xeomin is great for those that want to see the results set in faster. Often patients who consistently use Botox on a regular basis will switch back and forth between these two products.
Xeomin vs. Botox - Which is Better?
In my experience, which is a combination of using it in my practice and the literature I've read, the three neuromodulators are essentially interchangeable. The three are Botox, Xeomin and Dysport, and assuming equivalent dosages (50 units of Botox = 50 units of Xeomin = 150 units of Dysport) and that the preparations are equally fresh, I have as many people who prefer any one of them as any other. It is good to have choices and, in my opinion, there are now three excellent neuromodulators available.
I hope that this helps and good luck,
Web reference: http://www.bodysculpture.com
Xeomin & Botox & Dysport
Xeomin is fast onset as like Dysport in my study. Onset of Botox was late. Onset of Dysport was faster than Botox significantly. Potency of Dysport was stronger than Botox. I think Onset is Xeomin > Dysport >>>>>>>>>Botox. Duration (Potency) is Dysport >>>>>>>Xeomin > Botox. This is from my stydy. But many doctors have different opinion, so we should discuss about this onset & duration more detail in woril congress of meeting like IMCAS or AMWC. Dr Jongseo Kim, Antonio, Seoul Korea
These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.