Can you give me more information about the wrinkle treatment called Dysport?
What is Dysport?
Doctor Answers 26
Dysport is a competitor to the well known Botox aesthetic treatment. They both contain a neurotoxin, which is serotype A, surrounded by a protein. The main difference is the makeup of the protein.
Dysport and Botox: similarities and differences
Both Dysport and Botox have the same active molecule, which is the toxin that causes botulism (in dramatically higher doses.) It is a protein that is encased in other non-toxin proteins, so the difference is that Dysport has fewer of these so it is a smaller molecule. What this means in practice is that it spreads a little bit more and may take effect about a day sooner. In some areas, there is a softer transition from the affected area to the unaffected area, for a "softer" look. They both last the same amount of time.
Dysport is the latest neuromuscular blocking agent
Dysport is the latest neuromuscular blocking agent available. The generic name of the medication is abobotulinumtoxinA. Dysport is a direct competitor to botulinum toxin type A, trade name Botox(r). While there are technical differences between the two medications, the base content of both is botulinum toxin type A which causes paralysis of muscles by blocking the transmission of the chemical agent acetylcholine which tells muscles when to move. By paralyzing certain muslces of the face, the overlying skin wrinkles can be relaxed and wrinles produced with muscle motion will be reduced.
Dysport was approved for use in the United States in 2009 though it has been in use in other countries for several years. Dysport is approved for cosmetic use to treat the lines between the brows, the glabellar furrows. It is supplied as either a 300 unit or 500 unit vial and requires reconstitution. The doseage of Dysport is different from the dosing for Botox. The suggested starting dose for treatment of glabellar furrows with Dysport is 50 units as opposed to 20 units for Botox.
Dysport is reported to last about 3 months, though some studies have indicated it may last slightly longer. The current cost in the United States is less than the cost of Botox. Side effects are similar between the two drugs. The only additional warning that comes with Dysport but not Botox is that patients who have a milk allergy, not just lactose intolerance, should avoice using Dysport.
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Dysport = Botulinum Toxin type A
Dysport is abobotulinumtoxinA, which is another type A Botulinum toxin, analagous to Botox Cosmetic. It is just nicely on the US market, but has been used in Europe for nearly 20 years. It achieves the same results, be it muscle relaxation, wrinkle reduction, sweat elimination, etc. It is manufactured and sold by Medicis (maker of Restylane & Perlane) whereas Botox Cosmetic is manufactured by Allergan. Most practices are offering Dysport at a slightly lower price than Botox as an introductory offer, so you might be able to save a few dollars!
What is Dysport
What is Dysport
Dysport is an FDA-approved injection treatment that reduces the appearances of fine lines and wrinkles by relaxing facial muscles on the forehead. Similar to Botox Cosmetic, Dysport is injected directly into the site of wrinkles to prevent the underlying muscles from contracting.
Dysport has been studied in Europe since 1988, and has been available for use outside the US since 1991, and was approved for cosmetic use in the US in 2009. Dysport is another form of Botulinum toxin that is dosed differently than Botox, but is essentially the same. Both toxins inhibit the communication between nerves and muscles, resulting in the relaxation of the muscle and the disappearance of unwanted lines in the skin.
Dysport has been shown to deliver temporary improvement for frown lines, forhead, and crowsfeet and is FDA approved to last up to 4 months.
Botox Vs. Dysport
I use both Botox and Dysport in my practice, and both work well. Overall they are very similar in how they work and how long they last. While Botox is manufactured as a single molecular size, the size of Dysport molecules varies. Perhaps this explains why I have had some patients where Dysport works better than Botox and visa versa.
I posted an article in my San Francisco Plastic Surgery Blog with a more detailed comparison of the two drugs. A link to the article is supplied below if you would like to learn more.