What Are the Fundamental Differences Between Restylane and Perlane? Doctor Answers, Tips
Restylane: Q&A
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What Are the Fundamental Differences Between Restylane and Perlane?

Do Restylane and Perlane both act as dermal fillers with the same reults?

16 Doctor Answers | Asked by anon
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Restylane vs Perlane

As mentioned there are only minor differences between the two. This issue is where to place each of these fillers. That depends on your surgeon's experience and expertise. As we have significant experience with both of these we decide based on the finding on examination. it should be noted that many of the uses are FDA off label.
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How are Perlane and Restylane Different?

Hello. Restylane and Perlane are both hyaluronic acid fillers distributed by Medicis in the US. Both products main ingredient is a synthetic form of hyaluronic acid and naturally occurring substance in the body. Perlane is a thicker version of Restylane and is used in instances where more support is necessary. The cheeks and temples are great areas for Perlane. In addition, Perlane has a longer duration than Restylane. Depending on the area injected,... more
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Restylane and Perlane

As has been stated here by many, Restylane and Perlane are both hyaluronic acid fillers made by the same company, Medicis. Juvederm is hyaluronic acid filler made by a competing company, Allergan. In general, Perlane is a thicker product used for deeper fill and "adding volume" to the face, whereas Restylane is used more superficially in finer lines. Restylane is recently FDA-approved for lip augmentation as well. I have used Restylane and Juvederm in lips and I find they are... more

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Difference between Restylane and Perlane

Both products are hyaluronic acid fillers sold by Medicis. Perlane is a thicker product as a result of cross linking of the molecules. It is injected slighty deeper than Restylane. It is used when one wants to fill a deeper line such as deeper naso-labial folds and marionette lines. Restylane is used for more superficial naso-labial folds and what we call the tear trough area (which is below the eyes).
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Perlane for deeper correction, bigger problems

Restylane is a smaller particle than Perlane -the number of linked together subunits is fewer and cross-linking less. This gives a softer, smaller particle which is better suited for superficial corrections such as lips, eyelids, and wrinkles. Perlane is better suited for deeper correction such as deep nasolabial folds, cheeks and hollowing under the cheeks.
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What Are the Fundamental Differences Between Restylane and Perlane?

Great question. I tell my patients a very simplistic view. Restylane is one third less concentrated than Perlane or vice versa Perlane is 3x of Restylane. Not exact figures but very understandable.
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Restylane versus Perlane

Both are excellent fillers that I have used for years in my practice. They really are used differently though in terms of targeting. Perlane for a deeper line fill while Restylane is used for fine superficial lines. Basically , they last about the same and also, I use Restylane in the lips. It works great there and both are very safe.
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Perlane is a thicker product than Restylane.

I like to use Perlane in the laugh lines and marionette lines and for volumizing in the cheeks temples and brows. I like to use Restylane for the lips and for finer lines.
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What is the difference between Restylane and Perlane?

Restylane and Perlane are the same hyaluronic acid dermal filler with one exception. Perlane has bigger particles than Restylane and is more suitable for deeper, larger folds and wrinkles than Restylane. For example, I would use Restylane for under eye hollows and lips, but Perlane for nasolabial folds.
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Restylane and Perlane

Perlane is a larger hyaluronic acid particle size with more cross-linking than Restylane. Perlane, because of its larger particle size and increased cross-linking, has a larger G prime than Restylane. This means that its ability to lift tissue is greater. For this reason, I tend to like Perlane over Restylane in the cheeks.
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Restylane and perlane

Restylane and perlane are both hyaluronic acid fillers that are made by Medicis. Restylane is a smaller particle product and tends to last about 6 maybe 8 months. I usually reserve this for the lower eyelid region. Perlane is a larger molecule and usually lasts about 9-12 months.
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Perlane is thicker than Restylane.

Both are hyaluronic acid fillers. Almost anything that can be done with one can be done with the other. However, Restylane is slightly easier to deliver for superficial applications such as thin under eye areas or lip edge. Perlane is used more deeply where there is already a good layer of fat. It is typically used primarily used for deeper facial volume. It is excellent in the nasolabial folds, cheeks and chin.
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Difference between restylane and perlane?

They are both the same molecule but are cut into different particle sizes. What this means is that Perlane is bigger particles and is better for lifting and sculpting. Restylane is better for filling mid sized lines, lips and the area under the eyes. Each is a clear hyaluronic acid gel but the particle size makes them different. For Restylane, there are 100000 particles per mL of product. For Perlane, there are 10,000.
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Differences between Restylane and Perlane.

Restylane and Perlane are both hyaluronic acid fillers manufactured by the Medicis, the only difference is the size of the particle. Perlane has a larger particle size, lasts longer and costs a bit more than Restylane. Perlane last about nine months and Restylane lasts around six months. Generally Perlane is used for deeper filling and Restylane is used for more superficial filling however, these are just guidelines.
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Similar but different

Both products are excellent hyaluronic acid derivatives that are manufactured by the same company (Medicis). Perlane is more highly crosslinked and the particle size is larger than that of Restylane. Therefore Perlane is thought to last longer and is more appropriate for areas with larger volume deficits such as the nasolabial folds (smile lines). In the tear trough as well as in the lips, it is more appropriate to Restylane because of its smaller particle size. In any case, find an... more
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Restylane vs. perlane

Restylane and Perlane are both wonderful hyaluronic acid fillers but are usually used slightly differenly. Perlane is more highly cross linked and is firmer. It is made to inject more deeply and also probably lasts a bit longer. Resylane is softer for more superficial "finer" work. I sometimes will use restlane over perlane like a mattress over a box spring. So, yes they are both fillers but no, your doctor will probably have different uses for them.
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