Ask a doctor

What is the Most Effective Dosage of Spironolactone to Fight Acne?

I know it will vary from person to person, but I'm curious if there is a certain dosage that is considered the most effective for combating hormonal acne? I'm a petite mid-thirties female. I started on 100mg but felt poorly the first month I was on the prescription. I reduced my intake to 50mg, but wonder if I will not see the results with this lower dose?

Doctor Answers (2)

50mg of Spironolactone works well for hormonal acne with little side effects

+5

Spironolactone is an excellent medication for treating hormonal acne in females. Unfortunately, at higher doses it can have side effects (including dizziness and lightheadedness). I start nearly all of my patients on 50mg daily.  Spironolactone takes up to 3 months to have its full effect, at which point I will sometimes decrease the dose or may increase the dose of Spironolactone if necessary.  If you are currently taking 50mg daily, that is a great dose for most women with hormonal acne.

 


New York Dermatologic Surgeon
4.0 out of 5 stars 8 reviews

Aldactone for acne

+3

It works, particularly when a woman finds antibiotics both topical and systemic aren't working for that predictable perimenstrual flare.  You don't need large doses and often can take it only around your menstrual period..  I always suggest two weeks on and two weeks off.  I often start women on 25mg twice a day to see if that low dose is enough to block the hormonal hit.  I rarely have to take them to 50 mg twice a day.  Give the initial dosing at least one menstrual cycle to see if it works.  Two cycles are even better.

Hope that helps!

Steven Swengel, MD
Los Gatos Dermatologic Surgeon
5.0 out of 5 stars 4 reviews

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.