Restylane and Juvederm are both FDA-approved hyaluronic acid-based injectable filling agents. Often they are used interchangeably to fill various lines, wrinkles and furrows. However, there are differences in the physical characteristic between the various products, and others that are now available--such as concentration, particle size, ability to layer smoothly, provide lift, and impart durability--that allow experienced injectors to tailor agents to the specific needs of the individual.
For example, Restylane and its more robust relative, Perlane, are good choices when lift is needed. So, for deeper furrows, say around the nose or the angles of the mouth, Perlane might make a good choice and Restylane, a lighter product, might be used for creating or accenting the philtral columns. Juvederm Ultra Plus, which is a smoother product, but more robust than Juvederm Ultra, on the other hand, can be useful for plumping the body of the lips, while the Juvederm Ultra could be used to outline the vermilion border of the lips.
Another hyaluronic acid-based product, Belotero Balance, which has little tendency to cause bluish discoloration when injected superficially, makes a particularly good choice for treating the tear troughs.
Radiesse, an especially robust calcium-based product with good durability (results that last longer) makes a great choice for cheek, jawline and chin augmentations, alone or combined with one of the hyaluronic acid products mentioned earlier. The point is not which product is better, but which ones (either alone or in various combinations) is best for a particular individual. What should be clear is that a board certified aesthetic physician with extensive experience with all the available fillers and volumizing agents is necessary in order to achieve the best results.