Various agents can be used for melasma. Topical steroids are often combined within a "Kligman's" or "modified Kligmans" formula, and they can cause some skin thinning. However, hydroquinone does not cause skin thinning, and tretinoin or vitamin A in fact can thicken the skin a little as well as improve its texture and tone.
Does the combination of tretinoin and hydroquinone thin the skin?
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