I am thinking of gettting Botox for the first time and have been doing some research on the potential side effects. I have not been able to find clarification on this topic and would appreciate your feedback as it would ease my mind. Thank you!
If One Unit of Botox is Derived from a Lethal Mouse Dose How Many Units Would Kill a Human?
Doctor Answers (8)
the number of units of Botulinum toxin used to treat cosmetic indications are a fraction of those used by neurologists for dystrophic muscular cases and there is a high safety factor with those situations. Remember that one can not equate mouse studies with human results, the former are only used as a guide.
Consulting with a reputable, well-established, and experienced injector will provide you with all the information you need, regarding cosmetic Botox use. Potential side effects after cosmetic Botox injections are headache, localized pain, swelling, bleeding/bruising. Regardless of the number of units that are lethal to a mouse, it shouldn't have any correlation on your potential cosmetic treatment.
Lethal dose of Botox in a human
The mice used to test Botox weigh around 25g or 1/20th of a pound, sometimes less. The LD50 or dose required to cause death in half of mice injected with Botox is where the unit of Botox is derived. 1 unit kills half of mice injected after 3-4 days. Transferring this to humans, you'd need around 3000 units to kill an average sized person, or 30 100unit vials. Since the average cosmetic Botox injection is only around 30-50 units, you have virtually no chance of an adverse event such as death. You are much more likely to have an allergic reaction or not respond at all, both of which are also uncommon.
Web reference: http://utahoc.com/cosmetic_procedures.html
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How much botox would be dangerous
It would be next to impossible to run into problems with using quality cosmetic-grade Botox (e.g. made by Allergan). You would require at minimum 25 full vials of Botox injected in to you to have any problems, and this would never happen unless you had a death-wish.
The margin of error for Botox regarding its lethal dose is huge. It would take one to use over 25 vials to achieve the lethal human dose, which is not something that is a reasonable concern because it is way over the dosage used for cosmetic usages. You are generally better off seeing a physician who is in the front line cosmetic field such as a dermatologist or plastic surgeon.
Lethal Botox Dosage for Humans
It will depend on weight, but usually between 2500 and 3000 units for an average human would be a lethal dosage. Mind you this is full concentration, and if we're being technical, would be 25 to 30 full vials injected into one person. A normal full correction for an average person is no more than 50 units for the face.
Botox Lethal Dose
If you want to get technical, the LD50 for Botox is 2700 units for an average 70kg individual. If your surgeon is using anywhere near this amount of Botox, I suggest you run!
Put your mind at ease. Botox for cosmetic use (type-A) produced by Allergan when administered by a qualified plastic surgeon, has virtually no risk of being lethal. Side effects are usually mild and include bruising, headaches, and eyelid ptosis. Find a qualified plastic surgeon, and enjoy looking younger.
These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.
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