Possible to Never See Any Benefit from Tretinoin?

When used on a consistent basis, retin-A can be helpful for fine lines, wrinkles, pigmentation, and can stimulate collagen production. Much of this occurs when using the medication for several months. Initially, retin-A causes a micro-peel in which the surface layers of the skin exfoliate and existing acne is purged. This peeling and irritation may last for approximately 3-4 weeks and I usually recommend bland emollients during this phase. With persistent use the skin will... more

In most patients, it takes approximately 6 months to notice the anit-aging benefits of a topical retinoid like Retin A. This time lag is usually due to the period required for new collagen production to begin. The decrease in fine lines and other cosmetic benefits derived from a topical retinoid are subtle and usually can only be detected when comparing before and after photos.