Retin-A (tretinoin cream) should be applied in the evening to clean, dry skin at least 20 to 30 minutes after washing. The affected area is covered lightly and evenly. Temporary warmth or stinging may be felt. Sensitive areas to be avoided include around the eyes, nose, and mouth. Spot treatment should be avoided due to reduced efficacy and blotchiness. Patients are warned to expect temporary irritation with peeling that usually lasts up to 6 weeks. If the irritation becomes excessively bothersome, a several day break from treatment can be done. Moisturizing lotions can be applied, if necessary, after the tretinoin cream. I do not recommend you apply AHA treatments at night as this can be too irritating. It's safer to apply them in the morning.