When comparing Radiesse to a hyaluronic acid filler such as Restylane, it is important to understand the difference between "stimulatory" fillers and "wrinkle" fillers. When treating problems due to volume loss such as cheek hollows and sagging skin beside the mouth, I will almost always use stimulatory fillers such as Radiesse or Sculptra. They are injected deeper, beneath the skin, and will generate more volume to create a much better lifting effect for sagging skin. They work by stimulating your skin to produce more collagen, which is why they are so effective for problems due to volume loss. Hyaluronic acid gels like Restylane or Juvederm are used as wrinkle fillers because they are injected more superficially, being injected in the skin rather than beneath it.
The video link below shows me injecting my wife with Radiesse into the lower cheeks, marionette lines, and jaw line!