What type of streptococcus bacteria is Restylane fermented from?
Can Restylane Injections Cause Infections?
Doctor Answers (5)
There are no bacteria in Restylane
Restylane is derived, in the lab, from the fermentation of equine streptococcus, which is a form of beta-hemolytic strep. The important point is that the bacteria are used to create the chemical that is then processed into Restylane. There are no streptococci in Restylane, just like there is not Botulinum bacteria in Botox and no bread mold in penicillin.
Any filler can result in an infection. However that would most likely be the result of bacteria on your skin or in your system, not the bacteria used to create the product. Fortunately, infections following hyalauronic acid fillers are very rare.
Hope this is helpful.
Restylane is prepared from a fermentation process using a bacteria Streptococcus equi. This particular strain was chosen because it produces copious amounts of hyaluronic acid. It is then cross linked using a small amount of BDDE (butanediol diglycidyl ester). Since Restylane uses esterification in its process, it tends to be a bit "stiffer" than its Juvederm cousin. Also, the rare allergic reaction stems from a tiny remnant of BDDE which might be left over.
There is no danger of a bacterial infection since Q Med, the Swedish company that produces Restylane, uses the hyaluronic acid produced by the bacteria and not the bacteria itself.
Certainly you can get an infection. The skin should be properly cleansed and sterile technique employed rigorously. You certainly could get an infection from the dental block if this is performed. ( I received one when I was undergoing dental work last year myself.).
Also, as Dr. Janjua mentioned, you can develop an outbreak of herpes labialis since we are working around the mouth. This hopefully would be recognized early and treated appropriately.
Restylane causing Strep Infection
I am not sure whic Streptococcus is used to ferment Restylane but I doubt you could get an infection from Restylane because of that process. It is possible to get a herpetic breakout (cold sore) which can then get infected by streptococcus or more likely staphlococcus. However, that is not related to the product.
Improper handling i.e, not cleaning the skin with alcohol, not washing hands, not wearing gloves can transfer bacteria (staph or strep) to the injection sites and cause infection.
I have seen herpetic breakouts in areas other than lips as well and can look like mild blisters. Be on the look out for them as they can be hard to diagnose.
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Restylane, BOTOX, Facial contouring, cosmetic surgery
Restylane itself can not/will not cause an infection. You can develop an infection at the site of the injection by bacteria from the skin being introduced to the site...... however this is very unusual. i have seen 2 infections over the past many years and very few other minor complications. Restylane is a very safe soft tissue filler and can be used in the nasal folds as approved by the FDA and off label in many other areas of the face and body.
With Warm Regards,
Trevor M Born MD
Restylane and skin infections
If an infection is caused by an injection, it is the bacteria on the skin that creates the infection. The gram positive streptococcus bacteria is used in the laboratory for synthesis of the product, but the living bacteria do not get incorporated into the product so they would not be the cause of the infection.