Will Crease Line Disappear After Restylane Injections?

Lines and wrinkles to this area are related to the strong, purse-string-like action that the mouth muscle repeatedly performs. Although referred to as "smoker's lines", these wrinkles are not necesarily related to smoking and are a common problem for many people.
As the other panel members suggested, a good treatment plan will usually involve a small amount of Botox (to soften the action of this strong muscle), cosmetic dermal fillers (to fill the deeper wrinkles), and laser resurfacing with an ablative laser such as an Erbium MicroLaserPeel. Be certain to discuss all of the viable options with your practitioner, and don't hesitate to ask for before/after photos.
Please refer to the below link for further information/photos.

Restylane is useful for treating deep lines, not necessarily the fine lines around the mouth. Botox has a role, but must be used very carefully in order to avoid weakening the muscles that control smile and chewing/drinking. The best treatment for fine perioral wrinkles is a chemical peel and/or a laser treatment, not necessarily an injectable.
Please consult with a board certified plastic surgeon or dermatologist prior to treating this perioral area.

The fillers are used to raise major depressions or improve the contour. It is unlikely that it will efface a deep etched line on the face completely.