The most feared complication of filler injections is tissue necrosis. This is caused by the interruption of the blood supply to the affected area by direct injury of the vessel perfusing the area around the vessel, or obstruction of the vessel by filler material itself.
Fortunately, it is rare. In patients undergoing collagen injections, it as been in reported in nine of 10,000 patients. . Some areas such as the glabella, are at an increased risk, as has been reported for the...