Does Photodynamic Therapy Permanently Minimize the Sebaceous Glands?

will photodynamic therapy permanently decrease the size of the sebaceous glands or is it only temporary?

Doctor Answers (4)

PDT (Photodynamic Therapy) with Levulan will give long term but not permanent decreased size of sebaceous glands

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Levulan is absorbed preferentially in sebaceous glands.  After laser or light activation, there is "shrinkage" of these glands and therefore improvement in patients with acne.  After 2 or 3 treatments, there is long term control of acne (some have 5 years or more).  However, more commonly, yearly treatments are needed to control the acne because the sebaceous glands gradually grow back.  


Panama City Facial Plastic Surgeon
4.5 out of 5 stars 9 reviews

PDT for enlarged oil glands or sebaceous hyperplasia

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A published medical article demonstrated that sebaceous hyperplasia (enlarged oil glands) respond favorably to a series of PDT treatments.  However, PDT will not permanently reverse your likelihood to develop new lesions.  Maintenance PDT therapy or other destructive treatment options may be necessary from time to time to keep your skin clear of enlarged oil glands.

Melanie D. Palm, MD
San Diego Dermatologic Surgeon
5.0 out of 5 stars 12 reviews

PDT can shrink sebaceous glands

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PDT can be ab effective treatment for enlarged sebaceous glands, enlarged pores, and acne. ALA application followed by blue light may be necessary for best results.

Gary Goldenberg, MD
New York Dermatologist

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Photo Dynamic Therapy (PDT) and Sebaceous Glands

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Photodynamic Therapy (PDT) can temporarily shrink the sebaceous glands (think grape to raisin) for a period of time.  Sometimes when a few PDT sessions are administered in sequence (around every 3-4 weeks), the effect can last 6 months or longer.  At any rate, the effect is not permanent and usually one needs to have "booster" treatments to maintain the nice improvement.

Deborah Sarnoff, MD
New York Dermatologic Surgeon
5.0 out of 5 stars 4 reviews

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.