Photodynamic Therapy for Fordyce Spots?

While there is no clinical trials that validate the efficacy of photodynamic therapy (PDT) for treatment of sebaceous hyperplasia or Fordyce spots, you may have better clinical outcome if electrodessication is applied immediately prior to PDT.

Steevo deevo,

PDT has not been shown clinically to be effective against Fordyce spots. It is also unfortunately not covered by your insurance for the treatment of these benign spots. I agree with the others - I would try electrodessication or spot TCA to the areas to see if you get good results.  Typically Fordyce spots are difficult to eliminate completely. Good luck! - Dr. Mariwalla

Although this may be helpful for some patients and at a fair amount of cost, application of TCA (acid) on the lesions or gentle electrocautery should give you a more consistent result at less cost.