Perlane vs. Restylane, what's the difference?

Perlane and Restylane are similar products, made by the same manufacturer. They consist of the same substance - hyaluronic acid. The difference is in the particle size, with the Perlane having much larger particles. This in turn translates into the way we inject it: Perlane is usually injected deeper, with a... more

While the two products are Hyaluronic Acid based fillers, Restylane remains the "gold standard" as it allows for greater control and finesse. Medicis markets the larger particle (Perlane) to last at least 6 months, and Restylane to last up to 6 months. Both products should be injected by a trained... more

It is true that Restylane and Perlane are the same material made by the same company. The difference between the two is the size of the particles of hyaluronic acid. Restylane is smaller than Perlane. It is injected into the mid-dermis and is used for moderate wrinkles, lips and I do alot under the eyes... more

Restylane and Perlane are both hyaluronic acid fillers made by Medicis. Perlane has larger particle size and is thus more thick or dense and better suited for deeper fold or for deeper volume filling as in the cheeks. Restylane is the perfect choice for many patients but sometimes I choose Perlane... more

Great question. I would make a few suggestions. As you know that Perlane tends to last a bit longer than Restylane by perhaps 6-8 weeks or so (when injected in to the lips). You want to make sure that your doctor has experience with fillers in the lips as the lips require a great deal of skill and... more

Perlane is a more dense dermal filler. For example, Restylane can be used for very subtle changes, such as defining a cupid’s bow. Perlane is better suited for deeper facial folds and adding volume to larger areas, such as the cheeks or chin. Perlane can also be used for nasolabial folds.

Perlane is reserved for deeper folds and wrinkles and is placed slightly deeper under the skin while Restylane is used for more superficial wrinkles and lines. Both are excellent and can be used together. I typically do not use perlane in the lip area. They last equally long.

Great question.  Both products are hyaluronic acid. They differ in what is called crosslinking of molecules and of concentration of the hyaluronic acid in the product.  Restylane is generally softer and used for superficial wrinkles and lips. Perlane is firmer and is used for deeper wrinkles. Perlane... more

Think of them as starting from the same jello like substance and then pushing that jello through a strainer. If you use a pasta strainer then you get perlane. If you use a sifter for powdered sugar you get restylane. Forgive the food analogy but this seems to make sense to eveyone. As to what is best used in... more

Both Both are made by Medicis Both are hyaluronic acid based Both cost in the $500-600 dollar range in our office per syringe Restylane Comes in a "half" syringe (0.4 cc) Has a slightly smaller needle than Perlane for injections (thus it might hurt less) Can be injected more superficially Works... more