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Perlane vs Restylane: How is It Different?

From what I understand, Perlane and Restylane are made by the same company and do basically the same, what's the difference and why is Restylane so much more popular and talked about compared to Perlane? When is Perlane a better choice over Restylane?

Doctor Answers 7

Perlane is a larger particle.

Restylane and Perlane are both HA's.  They are safe, effective, and reversible.  The difference between these 2 substances is the particle size.  Perlane is roughly 3-4 times larger., making it very useful for the midface.

Dallas Facial Plastic Surgeon
5.0 out of 5 stars 36 reviews

14755 Preston Road
Dallas, TX 75254

Restylane vs Perlane difference

These 2 "cousins" are made of the same composition, hyaluronic acid. The difference is their size.  Restylane has 100,000 particles per ml and Perlane has 10,000 per ml.  So the particles are much bigger in Perlane.  This give Perlane more "strength" or G prime, a measure of it's lifting ability. Larger particles are harder for the body to degrade, so you get a little more longevity with the Perlane.  Both fillers have much more G prime than Voluma, or Juvederm.  Restylane Silk is 500,000 particles per ml and has less G prime than the others.

Steven F. Weiner, MD
Panama City Facial Plastic Surgeon
4.5 out of 5 stars 9 reviews

2050 W County Highway 30A
Santa Rosa Beach, FL 32459

Perlane and Restylane

On a microscopic level Restylane has a larger particle size. They also differ in the degree of cross-linking. They are both hyaluronic acid fillers used to treat essentially the same issues. However, Perlane, with a larger particle size is injected deeper in the skin than it's cousin Restylane. Hope that helps!

Brian Harmych, MD
Cleveland Facial Plastic Surgeon
5.0 out of 5 stars 3 reviews

29225 Chagrin Blvd.
Beachwood, OH 44122

Perlane and Restylane

Yes, they are made by the same company and do basically the same thing however, the molecule size of Perlane is much larger that Restylane and is better injected deeply, into larger areas of volume loss.

Sam Naficy, MD
Seattle Facial Plastic Surgeon
5.0 out of 5 stars 171 reviews

1110 112th Ave NE
Bellevue, WA 98004

Perlane vs Restylane


Great question and one that many people have questions about.  Perlane is a larger particle and is most often used for deep wrinkles (deep nasolabial folds), deep marionette lines or volume restoration. Restylane is made up of smaller particles and is used for finer lines, oral commissures, lip edges, tear troughs. Either can be used for the lips.  Though it is good for you to know the difference between the two and their uses, I would suggest leaving the choice of which filler to use where up to your injector.

Good luck~

Dr. Grant Stevens

Grant Stevens, MD
Los Angeles Plastic Surgeon
4.5 out of 5 stars 94 reviews

4644 Lincoln Blvd
Marina Del Rey, CA 90292

Perlane, Juvederm, Fill NLF's, Face Fillers, Restylane

Great question. 

  • Restylane is a smaller molecule soft tissue filler meant to be injected within the layers, of the skin, to fill in lines and superficial folds.
  • Perlane is made of the same material but has mor cross linking allowing a larger molecule size which is not meant to be injected within the skin but deeper into the fatty tissue below the skin for filling deeper folds and shaping areas like the cheeks, chin and Jawline.  In my opinion, Perlane last longer than Restylane.

Francis R. Palmer, III, MD
Beverly Hills Facial Plastic Surgeon
4.5 out of 5 stars 12 reviews

8500 Wilshire Blvd
Beverly Hills, CA 90211

Perlane vs. Restylane

Perlane and Restylane are both hyaluronic acids fillers made by Medicis. Perlane is more highly cross-linked than Restylane and so is thicker to inject and is better injected through a larger needle. Physicians differ in their use of the products, but in a nutshell, Restylane is for more superficial lines and wrinkles and lip augmentation (although I'm sure some use Perlane for this) and Perlane is better for deeper folds such as the smile lines and puppet lines (marionette lines). Perlane may last a little longer than Restylane, but this is not proven. As for why you hear more about Restylane it was approved by the FDA first and so it is a branded well recognized product. The company just needs to drive business to the injectors and then let the injector take it from there. Better to drive one brand name then spend half the money driving two.

Edward Buckingham, MD
Austin Facial Plastic Surgeon
5.0 out of 5 stars 37 reviews

2745 Bee Caves Road
Austin, TX 78746

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.