Pelleve delivers non painful radiofrequency energy throught the skin surface to the deeper dermis in which your body's fibroblasts produce collagen. Heating the dermis to a threshold teperature has been proven to produce new collagen. Treatment of Lyme disease patients was not done for acquiring data during the submission process ot the FDA during the initial studies. It is not known if there is any deleterious effect on the body's defenses against the progression of lyme disease by heating up the dermis. Although I would consider this to be doubtful, until a double blind placebo-controlled were to be performed, a physician could not state the treatment is in fact safe but they may suggest it as an off-label use.