What can be done on my face to make the most dramatic change to restore the youth and enhance my look? (photo)

I am 40 years old, when I don't smile, I look worn out and tired. I had fat transfer to my cheeks done back in June 2013. But I think it makes no difference in my appearance. I would like some suggestions as to what should be done to make my face look more fresh and youthful. I have one eye with double eye lid, one eye monolid, one side of face is always fuller than the other side. Nasolabial fold makes me look really old and my nose is too shallow for my strong jaws. What should I do

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