Thank you for the question. For first time injections in the depressor anguli oris (DAO), I generally use 4-5 units per side. The total cost would be about $125. Also, careful placement of a small amount of filler in the marionette folds (by the corner of the mouth) can also help with the down-turned appearance. These treatments can be done separately or together.
Botox or Xeomin can relax the muscles that pull the corners of the mouth down excessively. Usually about 8 units are required, for a fee of about $100. The effect usually lasts about three to five months.
Filler to augment the lips has a wide range of fees depending upon the amount of filler, the brand, and the area of the country. An average fee would be about $600.
To elevate the corners of the mouth you will typically need a facelift. Cheek implants probably will not do enough.