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Does Minoxidil Cause Wrinkles?

Doctor Answers (4)

Minoxidil affects collagen

+1

While minoxidil may not be main contributor to wrinkles, it does affect collagen. In the article, “Minoxidil: mechanisms of action on hair growth,” published in the British Journal of Dermatology 2004, it reveals minoxidil decreases the expression of lysine hydroxylase in collagen production. Additionally, it also suppresses collagen synthesis by rat vibrissae dermal papilla cells, both in monolayer cultures and in cells grown in collagen gels. Essentially, minoxidil can cause a degradation of skin’s collagen, which is what would probably cause the accelerated aging. However, skin problems are not listed as any of the side effects on the packaging of Rogaine or Spectral DNC.


Redondo Beach Dermatologic Surgeon
5.0 out of 5 stars 23 reviews

Wrinkles from minoxidil

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I have read no reports of minoxidil causing wrinkles. However, hair loss and wrinkles might happen at about the same time so someone might be able to do a study showing a relationship. It is not cause and effect. 

Jo Herzog, MD
Birmingham Dermatologist
5.0 out of 5 stars 12 reviews

Minoxidil and wrinkles

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Minoxidil is an antihypertensive medication with a side effect of promiting hair growth. Wrinkle formation is not a known or identified side effectof this medication.

Otto Joseph Placik, MD
Chicago Plastic Surgeon
5.0 out of 5 stars 48 reviews

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Minoxidil does NOT cause wrinkles

+1

To the best of my knowledge wrinkles are caused by aging, diet, stress, sun exposure among others. Minoxidil is not associated with wrinkle formation.

Peter A. Aldea, MD
Memphis Plastic Surgeon
5.0 out of 5 stars 63 reviews

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.