What Are the Medications That I Can't Take with Accutane?

You should always tell your treating physician about any OTC and prescription medications you are taking.  The most important interactions are high-dose vitamin A supplements and the tetracycline class of antibiotics (including tetracycline, doxycycline, and minocycline).  There are other potential interactions, but your doctor and pharmacist can alert you to these as well.  

Accutane is a derivative of vitamin A, so any multivitamins with vitamin A should be avoided.  Accutane can also have an effect on the liver, such as increased liver function tests, so any medication, such as for example oral antifungal medications or methotrexate, or substance, such as alcohol that affects the liver adversely should be avoided.  Acetaminophen (panadol) is one such medication. The list of such medications is long.  If you are prescribed a new medication,... more

It is most important to discuss all of your medical history, including all OTC and Rx oral and topical medciations with your prescribing dermatologist. The most important thing while on accutane is to avoid pregnancy. Tetracyclines can increase cerebral pressure and vitamin A can increase the retinoid toxicity of Accutane. Good luck and call your dermatologist to ask questions specific to your care.