Which Temporary Filler for Lip Augmentation Lasts Longest?

Restylane and Perlane are approved to indicate that they can last up to 6 months. Juvederm is approved by the FDA to say that it lasts up to a year. Everyone is different and in my practice it seems that injection into the lips lasts less time than injection into other areas of the face.

Juvederm lasts a bit longer than the other fillers, but I agree with my colleagues that lip augmentation enjoys the least longevity of all the locales fillers can call home. I am not sure if this has been scientifcally studied, but that is my impression also. If you take the time and have the inclination to read filler studies, you will note that nearly all of them involve the nasolabial fold. It is a much easier place to gauge and document depth and severity, the Lapiere scale, than other... more

Hi! Lip augmentation with Juvederm feels natural and lasts the longest. That's still only a few months, because the lips move so much. For lip definition (as opposed to augmentation),  we use Restylane.

The current fillers that I will use to increase lip size are JUVEDERM ULTRA, JUVEDERM ULTRA PLUS, RESTYLANE, or PERLANE. Despite FDA time tables for resorption, we have determined that injection into the lips lasts less time than into other areas of the face. This is most likely due to continual movement of the lip muscles which may break down the product faster and due to the vast blood supply to this area which may draw the product out of the system faster. I typically use JUVEDERM ULTRA... more

Juvederm seems to last the longest in my clinical experience. Restylane and Perlane last approximately 6 months. I agree that injection into the lips does not last as long as injection into the nasolabial folds, for example.

The fillers last different amounts of time but also the location of injection impacts their longevity as well.  As the studies have shown in the nasolabial folds, Perlane and Restylane last about 6 months, and Juvederm may last up to a year.