Can I have lip fillers safely as I have a mole on my upper lip (photo)

A mole on the upper lip would have no effect from having a filler, I suggest trying Belotero, this would give you the most natural result 

Unfortunately, I do not see the mole on your lip. If it's been there for many years, isn't changing, and grows hair, it may represent a nevus. And , your surgeon may consider a shave biopsy if it's on the white of your lip.Mole aside, you appear to be a good candidate for lip augmentation and filling the wrinkles around your mouth. In our practice, we prefer to use Silikon-1000, an off-label filler for permanent results.Hope this helps you.Dr. Joseph

There is no contraindications with the mole and lip enhancement.  Restylane or Juvederm are both fine fillers.