Is Hyaluronic Acid Absorbable by the Skin (Topical)?

Julie, Regarding your question about hyaluronic acid being absorbable through the skin. Products such as Restylane and Juvederm, two commonly used wrinkle fillers or plumping agents, will not cross the skin barrier. However, there are topical formulations such as Hydrating B5 gel, a Skinceuticals product, that will penetrate through the skin to hydrate the dermis.

The topical hyaluronic acid creams function in a different way then the injectable hyaluronic acid. The topical form is applied to the skin and act as a super moisturizer that hydrate the skin and plump it. Another thicker form of hyaluronic acid masks is used to attract more water from the air. Hope that helps.

Since Restylane is injected as a volume enhancer and wrinkle filler, I am not sure why you might be asking about transcutaneous absorption of the molecule. My guess however would be that it could not migrate through the skin barrier.

Hyaluronic acid is a normal substance found in the body and as such there is normal turnover. It is broken down by hyaluronidase (an enzyme). Not sure why you would put it on your skin; it would be an expensive skin cream! Good Luck!