Restylane: Q&A

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Is it Possible to Have a Flu Like Immune Response to Restylane?

iI have heard of some people having flu like symptoms after Restylane fillers, is it possible that the streptococcus bacteria that the filler is made from can give some people auto immune reactions like flu symptoms?

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4 Doctor Answers | Asked by julia8989

Doctor Answers (4)
Community Comments (2)

Is it Possible to Have a Flu Like Immune Response to Restylane?

Yes, it is possible. Best to return to injecting doc and contact the Medicius company is fill out an adverse reaction report.

Flu like immune response to restylane

Autoimmune responses such as Guillain-Barre have been reported following a "flu" (Influenza) or some other infections but NEVER after a strep infection. It is true that Restylane, purified from Streptococcal products, may contain trace amounts of Strep proteins but it is extremely unlikely for a person, even sensitive to Strep, to get any reaction as strong as a "Flu" symptom, and even then, no autoimmune reaction would be likely to follow. Restylane... more

Restylane is an excellent soft tissue filler for facial rejuvenation

While it may theoretically be possible, I have never seen it nor have I heard of it reported at any of the numerous scientific meetings I have attended both nationally and internationally. I would still take it seriously and treat it as you would do the flu. If the symptoms recur and are similar or worse after your next treatment I would definitely report it to your doctor so they can report to the company as well.

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Medicis, the distributor of Restylane, warns doctors of this possibility.

Julia The filler is not make from the bacteria, it is made by the bacteria. Many steps go into the process of preparing this very high grade product for human use. However, a tiny percentage of individuals with allergies to bacteria antigens are warned about the possibility of allergic reactions due to this exposure. It is important to stress that this is rare. It is much more likely that any flu like symptoms after a Restylane treatment will be cause by... more

Kenneth D. Steinsapir, MD

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Los Angeles Oculoplastic Surgeon

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Comments (2)

MBAgirl
9 Mar 2013

I have been having flu symptoms and just learned of enlarged lymph nodes in my lung and I seem to have most symptoms of sarcoidosis :-( it is an autoimmune disease which is treated with prednisone which i started today. If any of you have not tried prednisone for these symptoms you may consider it.

MBAgirl
4 Mar 2013

Hi, According to the FDA, Adverse Reactions should be be reported by calling Medicis Aesthetics at 1-866-222-1480. Also review this FDA document regarding antibody testing: http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/MedicalDevices/MedicalDevicesAdvisoryCommittee/GeneralandPlasticSurgeryDevicesPanel/UCM252491.pdf

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