Does Hyaluronidase Always Work? Doctor Answers, Tips
Hyaluronidase: Q&A
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Does Hyaluronidase Always Work?

Hi I had a nurse friend inject a generic HA dermal filler from china under one of my tear troughs. I had a bad reaction hot red and was put on antibiotics and prednisone. My doctor injected it with hyaluronidase because I wanted this stuff out of my body. It feels like rubber under my eye. How long does it take for this hyaluronidase to work? I've had it done before and it worked overnight. This filler isn't budging which leads me to believe it is not HA.It is something more permanent.I am upset.

4 Doctor Answers | Asked by 764439anon in NY
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Persistent bulge after hyaluronidase treatment

If more hyaluronidase does not help, your doctor may want to consider that it may be a granulaoma, biofilm infection or a material other than hyaluronic acid. A biopsy and culture would be the next step if you are having problems. The microbiology culture will need special stains and be run for 6 weeks.Depending on the results, your doctor may consider treating you with a long course of antibiotics, a steroid injection, or surgical removal.
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Hyaluronidase failures

I would agree with the two posts thus far, but will add another thought.  H'dase is dose dependant, so it is possible that a little more will get you more results.  It depends on the original dose your physician used, and it's location relative to the filler.  So follow up with your physician, and discuss the possibility.  You are right, it can have it's influence within a day or two under normal circumstances. If that is not the case, then I too would... more
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Fller

You have been injected with an illegal, NON FDA approved substance. I understand you are ipset and you should be upset at your friend as well, who should be stopped from harming other people. Work with your doctor, But do not expect miracles
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Hyaluronidase for dissolving filler

You may not be seeing the typical quick action of hyaluronidase because either, the filler had other additives or fillers, or there is an infection. You may need antibiotic coverage which the specialist would have to consider. There always is a concern when non-FDA approved items are used as you truly do not know what you are getting.
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