Can a person become hypersensitive to Botox?

Five years ago, I gave Botox a try for migraine and cosmetic use. I liked the results for cosmetic but the jury was still out for migraines.

Last year, on March, I decided to try a "migraine protocol" that my neurologist recommended. Unlike the 20-27 units I was getting for cosmetic reasons, the protocol was for 100 units (all over the head). I experience some new and very scary side effects that included eye droop and swelling of the lids.

One year has passed and I went to my dermatologist who has been administering the Botox for the past 5 years without problem. That night, I could feel the tingling in my face and left eye which was most effected before. Today, there was more eye drooping, burning eyes, and swollen lids.

I have personally decided that I can no longer tolerate Botox. Am in danger of the eye droop not correcting itself since this is a second bad episode? I received 21 units forehead received 12 units and 9 units between the brow. Thank you!

5 answers to “Can a person become hypersensitive...”

A: Sensitivity to Botox

Steven H. Williams, MD

Thanks for your question - I have not seen acquired Botox sensitivity described in the literature.  Eyelid drooping after Botox injection can happen in the medication is administered in the wrong area or if you have a significant amount of lid skin excess that your frontalis muscle is working to keep out... more

A: Interesting

Christopher L. Hess, MD

Your question intriqued me. So I did an extensive literature search to see if a person could build up sensitivity or immunity to botox. None of the literature suggests that this is possible. Even the eyelid is not significantly depicted. So unfortunately you've had now two physicians that don't know how to... more

A: Botox Reactions

Daniel Reichner, MD

I would recommend that you stop the Botox treatments. They do not seem to be helping with your original problem - the migraine headaches and you developing a drooping eye two times. I suspect that you are not "sensitive" to Botox, rather, it is more likely a technique problem or you have a... more

A: Tingling, burning eyes, swollen lids with Botox

Bryan K. Chen, MD

You are experiencing unusual side effects related to your Botox injections.  I suggest that you bring these signs/symptoms to the attention of your dermatologist.  These unusual symptoms do not seem like a true allergic reaction to me.  Life-threatening symptoms to watch for include wheezing,... more

A: Rpeated use of Botox and eyelid drooping

Otto Joseph Placik, MD

I can understand your concerns. However, it is very likely that you will return completely to normal once the Botox effect has dissipated which is typically 5 months at the most. To answer your title question, it is not common to develop hypersensitivity to the Botox with repeated use. In fact, some studies... more

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