Does Hyaluronidase Remove the Original Collagen in the Under Eye Area if Used to Dissolve Juverderm? Doctor Answers, Tips
Hyaluronidase: Q&A
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Does Hyaluronidase Remove the Original Collagen in the Under Eye Area if Used to Dissolve Juverderm?

Is Hyaluronidase the only substance that can dissolve Juverderm? My doctor said that if they remove the Juverderm it will remove 80% original collagen and 20% juverderm. Is this some misinformation, or is this a known risk & side effect?

8 Doctor Answers | Asked by anon
+5

Hyaluronidase Will Not Affect Your Natural Collagen

You have no worries as far as collagen loss with the injection of hyaluronidase. Prior to the days of hyaluronic acid fillers, hyaluronidase was used to help local anesthetic injections over a wider area. Volume loss and/or collagen loss is not a side effect.
+5

Hyaluronidase and your natural collagen

No. Hyaluronidase does not affect your natural collagen or injected collagen. It is an enzyme that targets hyaluronic acid directly. Other enzymes called collagenases that your body produces will break down collagen, but these enzymes tend to be very specific with their targets.
+4

Hyaluronidase will only affect hyaluronic acid

Hyaluronidase will only target the hyaluronic acid and not the collagen. You will not see any side effect of volume loss or atrophy. Best regards!
+3

Does Hyaluronidase Remove the Original Collagen in the Under Eye Area if Used to Dissolve Juverderm?

No, the hyaluronidase that's injected only dissolves the hyaluronic acid filler that in the same vicinity, not the host tissues.
+3

Does Hyaluronidase Remove the Original Collagen in the Under Eye Area if Used to Dissolve Juverderm?

No worries at all. hyaluronidase dissolves hyaluronic acid not collagen, and your body makes it about every 80 hours. Best Dr. Malouf
+3

Hyaluronidase targets hyaluronic acid only

Hyaluronidase is an injectable enzyme that targets hyaluronic acid only, not collagen! Not even the old school injected collagen would it affect! The statement is flatout incorrect, because quite frankly if it did this, none of us would be using it!!!
+2

Hyaluronidase Leaves Collagen Alone

Hyaluronidase will only break down hyaluronic acid, it will have no affect on collagen. The body will manufacture the missing hyaluronic acid by the way so there is not future problem. I think it is very important to ask your physician whether he/she has hyaluronidase available in case there is an emergency. Vascular compromise by Restylane/Perlane, Juvederm or Belotero can be a disaster. Hyaluronidase is the best weapon to prevent that. The recombinant variety, though more... more
+2

Will Hyaluronidase Dissolve Normal Collagen

NO! Hyaluronidase will not harm normal collagen or the surrounding tissue. It will only dissolve the hyaluronic acid. Not to worry.
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Comments (1)

analei14 3 Nov 2012
I had hyaluronidase injected under one of my eyes to remove excess Juvaderm. The procedure not only dissolved the Juvaderm but left my ENTIRE cheek flat and deflated. The dermatologist who did the procedure claimed that he used "a very conservative" amount. However, even this conservative amount affected my natural tissue. Please proceed with caution. Based on my own experience, it seems that hyaluronidase does affect natural tissue.

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