Cortisone Injection and Restylane-caused Granuloma

Dear Dandoons Granulomas from Restylane are rare indeed! So rare in fact that is is much more probable that your issue is either overfill or some type of cellulitis unless the reaction has been biopsied. An actual consultation is needed to clarify this issue. Just because you may have been told that you have a granuloma, which might be true. The first step in dealing with any Restylane issue like this is to fully disolve the filler with the enzyme Hyaluronidase. This will break down the... more

Hi Dandoons, Sorry to hear about your adverse event with your Restylane injections. Make sure that what you are feeling is a granuloma and not just too much residual Restylane. If it were Restylane then hyaluronidase should be useful. If it is a true granuloma, then Kenalog injections as recommended by the other physicians should help. Good luck and be well. Dr. P

The standard cortisone injectable solution is Kenalog (triamcinolone acetonide) solution. I typically use 2.5 mg/mL concentration. Care should be taken to direct the injections into the granulomas themselves and not the surrounding tissue to minimize the potential atrophy effect of cortisone. Injections can be as frequent as every 3 weeks, as needed. You should be reassurred, however, that even if atrophy occurs, it usually self-corrects on its own. If you in fact have... more

Most physicians who do these injections prefer Kennalog. I like kennalog 2.5 mg./5cc. The injection is given directly into the granuloma. There is usually no complication but there can be fat atrophy or color change on rare occasion. The fat eventually returns to normal and the pigment comes back too. The amount injected is very small and it is diluted. For that reason there are no other side effects, ie. it does not travel throughout the body.