The first generation Fraxel was called Fraxel 750, the second Fraxel SR1500, both are now renamed Fraxel re:store, erbium fractionated non-ablative lasers that help correct mild to moderate skin wrinkles and brown spots, acne scars, and melasma.
The difference between the 1'st and 2'nd generation re:store Fraxel lasers was a $30,000 "upgrade" fee paid to Reliant, and alleged improved results because of an aperture on the SR1500 laser that adjusted the size of the laser spot along with changes in depth.
Clinically, after having used both, I did not see much of a difference between the first and second generation. I still use the Fraxel SR1500 in selected patients. For wrinkles and skin tightening, both of the re:store models don't come close to the results obtained from a single treatment with Fraxel re:pair, a fractionated carbon dioxide ablative laser treatment. For patients who desire dramatic results, and are willing to put up with increased social downtime, Fraxel re:pair is the way to go.
All is not lost though, we have found that patients who have had previous Fraxel re:store treatments do very well with Fraxel re:pair treatments (there is an additive effect).
Los Angeles, CA