Evolence is a porcine (pig) collagen-based filler. Unlike the first generation collagen fillers, Zyplast and Zyderm which are bovine (cow) derived, skin test is not required. There tends to be less swelling associated with Evolence, as compared to some of the hyaluronic... more











52 posts
7 Jun 2008
Juvederm & Restylane Juvederm and Restylane are hylauronic acid-based fillers. They last at the most 6 months in the skin and require repeated filling. Evolence Evolence is a filler that is collagen-based and cross-linked with D-ribose. It lasts longer than the Restylane and Juvederm. I tend to find that the Evolence gives a much more natural and a longer lasting fill. In some patients, I have seen the hylauronic acid fillers last only 3 months in the lips, and the Evolence generally gives longevity. Also the costs for the Evolence are roughly the same as hylauronic acid fillers, so this works in the patient's favour.
138 posts
25 Sep 2008
As has been stated before, Evolence is made out of Collagen, not Hyaluronic Acid. It is made in Isreal out of the achilles tendons of pigs. The material is altered with enzymes to make it nearly identical to human collagen. So far, there has not been even 1 case report of an allergic reaction to this product, so no skin testing is required! It probably lasts longer (about 1 year), it causes less bruising and very little swelling. All of this is good news! BUT....since it is made out collagen, I don't think there are any approved chemicals to dissolve it. If you go to an inexperienced injector, and you get a bump, you are probably going to have to live with it until it dissolves. This is no different than using Radiesse, and I use Radiesse all the time with great results, so I don't think this is going to be a major problem. Michael J. Sinclair, MD www.epilution.com