Evolence - how is it different from Restylane or Juvederm?

Evolence is made of protein from pig collagen. Restylane and Juvederm are laboratory synthesized hyaluronic acids which are found in the normal skin's infrastructure. There may be more bruising with the hyaluronic acids than Evolence.

Evolence is a cross linked collagen. HA, or hyaluronic acid, which is the primary ingredient in Juvederm and Restylane, are a different compound and most of the effect of the substance in facial filler applications is due to water absorption from surrounding tissues.

Johnson & Johnson (the maker of Evolence) obtained FDA approval to market the compound in the United States on June 30, 2008. They have indicated that it will be available as soon as they can train physicians in its use. Additionally, J&J has applied to the US FDA for an indication that Evolence lasts up to a year, though this indication is currently being investigated.

According to the J&J website:

"This new generation collagen filler is intended for injection into the mid-to-deep dermis for the correction of moderate to deep facial wrinkles and folds, such as nasolabial folds. The most common side effects of EVOLENCE®injections are usually injection-site related and include mild swelling, redness, and pain. Other rare side effects include the development of small areas of firmness under the skin at the treated sites that may be noticed when the areas are pressed upon."

Juvederm & Restylane

• Juvederm and Restylane are hylauronic acid-based fillers.
• They last at the most 6 months in the skin and require repeated filling.

Evolence

• Evolence is a filler that is collagen-based and cross-linked with D-ribose.
• It lasts longer than the Restylane and Juvederm.
• I tend to find that the Evolence gives a much more natural and a longer lasting fill.
• In some patients, I have seen the hylauronic acid fillers last only 3 months in the lips, and the Evolence generally gives longevity.
• Also the costs for the Evolence are roughly the same as hylauronic acid fillers, so this works in the patient's favour.