Dysport Work for a Botox-resistant Patient?

Dysport and Botox while both a botulinum toxin, they are different and therefore Dysport may work for your grandmother.

I have seen patients who respond to Dysport but not Botox. I would also suggest looking into Xeomin which was recently approved to treat cervical dystonia in the US. It is also a botulinum toxin type A product.

Botox resistance is rare in my 15 year experience, and it may be worthwhile to try Dysport.  Make sure you consult with an experienced injector of Botox or Dysport. Ramtin Kassir, MD NY/NJ facial plastic surgeon

I personally have had patients who responded well to an equivalent dose of dysport when botox did not work well after a while for essential blepharospasm.  The compounds are similar but not exactly the same. It is hard to determine why the dysport at the same corresponding dosage would work when botox would not but I have a multiple of patients who have had that response. 

Most of the time when a man or an older woman does not respond well to Botox, it's typically a matter of not enough Botox units got injected to the desirable areas. True resistance to Botox is exceedingly rare. I do have patients for whom Dysport may work a little better than Botox and vice versa. Myobloc may work better but not yet FDA approved for cosmetic usage.

Dysport is a close relative of Botox that is now available in the United States through Medicis. We have seen great results in patients who have previously used Botox or have developed a resistance, or in patients new to these muscle relaxers. If you have use Botox but have not been satisfied with the results, you may consider using Dysport and you may consider a stronger concentration of Dysport as you may have stronger muscles in this area. The amount of Dysport used is slightly... more

Dysport and Botox are both Botulinum Toxin type A products. They are, however, subtly different. It is this small difference that may account for Dysport working where Botox does not. In my practice I have treated a couple of patients that don't respond to Botox injections. They seem to be doing well with Dysport so far. Traditionally we have used Myoblock for these patients, but Dysport presents another options. I would recommend trying Dysport if you find that Botox is not effective.... more

There are many patients who present to a plastic surgeon's office complaining that they need more and more Botox with continued use. It is completely feasible and theoretically possible that these patients should benefit from Dysport or Myobloc. 

Hello, Some patients who are resistant to Botox A (Botox) seem to respond to Botox B (Myobloc). Myobloc is FDA approved and I have found it safe and effective in my practice over the last three years.

It may. While there may be a number of reasons someone may have achieved an unsatisfactory response to Botox, true Botox resistance is very uncommon. It is best to consult with a qualified physician to determine which of the botulinum toxin products would be most likely to produce optimal results. Review of medical records that indicate the dose and placement of previous botulinum toxin injections can help determine how to achieve improvement with subsequent treatments....

Botox, Dysport and Myobloc are all produced from the bacteria Clostridium Botulinum, the bacteria causing deadly botulism ( Bon Vivant vichyssoise soup 1971 contained this). These neurotoxins were originally isolated in 1946 at Fort Detrick in Frederick Maryland ( Camp Detrick back then) to be used as bacterialogical warfare. Clostridium Botulinum produces seven distinct neurotoxins that are all neuromuscular paralyzing agents. The toxins are called botulinum toxin type A,B,C1,D,E,F... more