Does a vial of Botox come pre-mixed?

I have heard Botox has to be mixed each time it is used. Is this true, or does it come pre-mixed? Thanks.

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14 answers to “Does a vial of Botox come pre-mixed?”

A: Botox does not come pre-mixed

Steven E. Rasmussen, MD

As answered by my colleagues before me, Botox comes as dried powder that must be kept refrigerated. The vial contains either 50 or 100 units. It is reconstituted in normal saline prior to your treatment. There is no set volume of saline that is used. It is up to the individual provider. It ranges... more

A: Botox comes in a concentrated powder

Jordana S. Gilman, MD

Every vial of Botox gets diluted when it is used.  Doctors may use different amounts of saline to dilute the powder, resulting in Botox that is more or less concentrated.  Depending on the areas being treated, one vial may be enough for 3 patients or it may only be enough for one patient.

A: Botox does not come pre mixed

Darrick E. Antell, MD

Botox is stored in a cold environment and has no liquid in it when the manufacturer delivers it. We generally use a minimal dilution as I think more concentrated Botox allows us to use fewer needle sticks.  Others dilute it more, but my concern is that higher dilutions may not last as long.

A: Botox is mixed the first time it is opened

Ronald Shelton, MD

It is mixed every time it is first opened. The same bottle has enough units of Botox to treat two to three cosmetic units. This rarely is all done on the same patient, and more commonly provides doses for two or three patients.

A: Each bottle needs to be mixed by the doctor's office

Richard P. Rand, MD

Botox comes from the manufacturer as a dry powder in a small vial. It needs to be reconstituted to its active form by the office using it. The concentration can vary depending on how much saline is added to the 100 unit vial.

A: Botox--Injector Picks Dilution

Anil R. Shah, MD

Botox does not come premixed. It comes freeze dried (kinda like astronaut food). The injector will help pick the dilution of botox depending on the intended application. Once botox is mixed it should ideally be used within 4 hours of reconstitution but this number is controversial. Botox can be made more... more

A: Botox does not come pre-mixed.

Sanjay Grover, MD

Botox does not come pre-mixed and needs to be reconstituted with normal saline prior to injection. Once mixed, the effectiveness of Botox can last for a certain period of time.   Everyone dilutes their Botox with different amounts of normal saline, thus you should know how many 'units' of Botox that... more

A: No, it does not come premixed in liquid.

Charles Crutchfield, MD

Botox Cosmetic does NOT come premixed in liquid.  It comes as an extremely small amount of powder in a vial that is 'lyophilized', which is a fancy term for 'freeze dried".  Botox cosmetic is measured in units.  Units are a way of measuring the acrtivity, so all vials will have the same... more

A: Botox Cosmetic by Allergan is available in a 100 unit multi-dose vial for injection of wrinkles

Raffy Karamanoukian, MD

Botox cosmetic is manufactured by Allergan.  This is the same company that manufactures Natrelle breast implants. Botox is available in the United States in two different packages: Botox Serotype A for cosmetic use and Botox Serotype A for medical use. Only Botox cosmetic should be used by your physician... more

A: Botox is packaged as a dried product.

Bryan K. Chen, MD

Botox does not come pre-mixed.  It only needs to be mixed one time with sterile saline.  If possible, Botox should be mixed just prior to injection.

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