Does Juvederm Stimulate Collagen Growth?

Although most long-time injectors as well as patients have believed that repeated use of cosmetic dermal fillers led to collagen stimulation -- it is now supported with research by both Allergan and Medicis. Many users will experience this by realizing that they need less product and may go longer between treatments. This concept of collagen stimulation is also true of many class IV medical lasers.

The other consultants have referenced the article, which suggests that Restylane induces the formation of collagen by causing swelling and subsequent recruitment of the cells responsible for collagen production. All of us who have been injecting hyaluronic acid products since they were released in 2000, have observed a "retention" of effect, especially in the lips, after repeated treatment. What is not clear is whether the collagen stimulated is Type I (desirable "de... more

Juvederm is a hyaluronic acid, much like Restylane. Restylane has been shown to stimulate collagen growth but not because of the actual filler, but because of the spreading of the collagen fibers induced by the injection into the skin. The fillers that clearly stimulate significant amounts of collagen are Radiesse and Sculptra. To your health,Dr. David Goldberg

A nice article from 2007 showed that collagen is stimulated by injections of hyaluronic acid. Restylane and Juvederm should both stimulate collagen production. 1: Arch Dermatol. 2007 Feb;143(2):155-63. In vivo stimulation of de novo collagen production caused by cross-linked hyaluronic acid dermal filler injections in photodamaged human skin. Wang F, Garza LA, Kang S, Varani J, Orringer JS, Fisher GJ, Voorhees JJ