It is common to see acne flare during the first month of Accutane (isotretinoin, isotane) therapy. Usually this flare subsides after a few weeks with continued therapy. In a small number of cases, these flares can be severe with large, painful draining cysts and nodules. In these cases, therapy can be stopped until this reaction subsides. The medication can then be restarted, often at a lower dose so this doesn't happen again.